Type 2 diabetes; neurodegenerative diseases; lipid peroxidation; antioxidants; iron nitrosyl complexes; fullerene C60 derivatives; enzymatic targets of diseases;

RF patent for invention No. 2669341. Use of pentaamino acid derivatives of fullerenes as antioxidants and antidiabetic agents. // Kotelnikova R.A., Areshidze D.A., Soldatova Yu.V., Smolina A.V., Kozlova M.A., Semin I.A., Zhilenkov A.V., Troshin P.A., Kotelnikov A.I., Aldoshin S.M.; Appl. 6.04.2016. Published 10.10.2018 Bull. No. 28. (Application No. 2016112993 of 04/06/2016)

• 1Soldatova, Y.V.; Faingold, I.I.; Poletaeva, D.A.; Kozlov, A.V.; Emel’yanova, N.S.; Khodos, I.I.; Chernyaev, D.A.; Kurmaz, S.V. Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone. Pharmaceutics 2023, 15, 1388. https://doi.org/10.3390/pharmaceutics15051388 

• Poletaeva D.A., Faingold I.I., Soldatova Yu.V., Smolina A.V., Savushkin M.A., Sanina N.A., Aldoshin S.M. Interaction of iron nitrosyl complexes with the membrane of phosphatidylcholine liposomes: a fluorescent study // Journal of Physical Chemistry, Nauka, M., V. 97, No. 5, 2023 P. 617-623. https://doi.org/10.31857/S0044453723050217 

• Soldatova Yu.V., Areshidze D.A., Kozlova M.A., Zhilenkov A.V., Kraevaya O.A., Faingold I.I., Troshin P.A., Kotelnikova R.A. Hypoglycemic and hypolipidemic effect of pentaamino acid fullerene C60 derivative in rats with metabolic disorder. // Journal of Bioenergetics and Biomembranes 2023, https://doi.org/10.1007/s10863-023-09961-y 

• Soldatova Yu.V., Zhilenkov A.V., Kraevaya O.A., Troshin P.A., Faingold I.I., Kotelnikova R.A.Antioxidant and antiglycation activity of pentaamino acid derivatives of С60 fullerene. Nanotechnologies in Russia (Nanobiotechnology Reports) 2022,  Vol. 17, № 6, P. 840–845. https://doi.org/10.1134/S2635167622060118 

• Poletaeva, D.A.; Soldatova,Y.V.; Smolina, A.V.; Savushkin, M.A.; Klimanova, E.N.; Sanina, N.A.;Faingold, I.I. The Influence of Cationic Nitrosyl Iron Complex with Penicillamine Ligands on Model Membranes, Membrane-Bound Enzymes and Lipid Peroxidation. Membranes 2022, 12 (11), 1088. https://doi.org/10.3390/membranes12111088 

• Avilova I.A., Chernyak A.V., Soldatova Yu.V., Mumyatov A.V., Kraevaya O.A., Khakina E.A., Troshin P.A. and Volkov V.I. Self-Organization of Fullerene Derivatives in Solutions and Biological Cells Studied by Pulsed Field Gradient NMR. Int. J. Mol. Sci. 2022, 23, 13344. https://doi.org/10.3390/ijms232113344 

• Kurmaz S.V., Fadeeva N.V., Skripets J.A., Komendant R.I., Ignatiev V.M., Emel’yanova N.S., Soldatova Yu.V., Faingold I.I., Poletaeva D.A. and Kotelnikova R.A. New water-soluble forms of a-tocopherol: preparation and study of antioxidant activity in vitro // Mendeleev Communications – 2022. – Vol.32. – P.117–119. https://doi.org/10.1016/j.mencom.2022.01.038  

• Faingold I.I., Poletaeva D.A., Soldatova Yu.V., Smolina A.V., Pokidova O.V., Kulikov A.V., Sanina N.A., Kotelnikova R.A. Effects of albumin-bound nitrosyl iron complex with thiosulfate ligands on lipid peroxidation and Activities of mitochondrial enzymes in vitro. //Nitric Oxide, 2021. – Vol.117. –P.46-52  https://doi.org/10.1016/j.niox.2021.10.002  

• Soldatova Yu. V., D.A. Areshidze, A.V. Zhilenkov , O.A. Kraevaya, A.S. Peregudov, D.A. Poletaeva, I. I. Faingold, P. A. Troshin, R. A. Kotelnikova. Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats.// Journal of Nanoparticle Research, 2021. – Vol. 23. – №. 202 P. 1-13 https://doi.org/10.1007/s11051-021-05313-2 

• Kurmaz S.V.; N. V. Fadeeva; Soldatova Y. V.; I. I. Faingold; D. A. Poletaeva; V. M. Ignat'ev; N. S. Emel'yanova; G. V. Shilov; R. A. Kotelnikova. New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus. // Journal of Polymer Research, 2021. – Vol. 28. – №. 345. - P. 1-15  https://doi.org/10.1007/s10965-021-02684-x 

• Kurmaz S.V., Fadeeva N.V., Grishchuk A.A., Emel’yanova N.S., Ignat’ev V.M., Shilov G.V., Soldatova Yu.V., Faingold I.I., and Kotel’nikova R.A.. Hybrid Materials Based on Dimethylbiguanide (Metformin) and Copolymer of N-Vinylpyrrolidone with Triethylene Glycol Dimethacrylate // Polymer science series A. – 2021. –Vol. 63, No. 2. – P.106-116. –https://doi.org/10.1134/S0965545X2102005X    

• Avilova, I.A., Soldatova, Y.V., Kraevaya, O.A Zhilenkov A.V., Dolgikh E.A., Kotel'nikova R.A., Troshin P.A., Volkov V.I. Self-Diffusion of Fullerene С60 Derivatives in Aqueous Solutions and Suspensions of Erythrocytes According to Pulsed Field Gradient NMR Data. // Russian Journal of Physical Chemistry A, 2021. – Vol. 95, №2 – P.285–291.  https://doi.org/10.1134/S0036024421020047  

• Makhaeva G. F., Kovaleva N.V., Rudakova E.V., Boltneva N. P., Lushchekina S.V., Faingold I.I., Poletaeva D.A., Soldatova Y.V., Kotelnikova R.A., Serkov I.V., Ustinov A. K., Proshin A.N., Radchenko E.V., Palyulin V.A., and Richardson R. J. New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment. Molecules. 2020.  – Vol. 25. – №. 24. – P. 5891. https://doi.org/10.3390/molecules25245891  

• Soldatova Yu. V., Kotelnikova R. A,. Zhilenkov A. V, Faingold I. I., Troshin P. A., Kozlova M. A., Areshidze D. A., and Academician of the RAS Aldoshin S. M. Potassium salt of fullerenylpenta-N-dihydroxytyrosine effects on type 2 diabetes mellitus therapeutic targets. // Doklady Biochemistry and Biophysics, 2019. – Vol. 488. –  № 1. –  P. 320-323.  DOI: https://doi.org/10.1134/S1607672919050089  

• Faingold I.I., Kotelnikova R.A., Smolina A.V., Poletaeva D.A., Soldatova Yu.V., Pokidova O.V., Sadkov A.P., Sanina N.A., Aldoshin S.M. Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro // Doklady Biochemistry and Biophysics. – Pleiades Publishing, 2019. – Vol. 488. – №. 1. – P. 342-345. https://doi.org/10.1134/S1607672919050120 

• Poletaeva D.A., Faingold I.I., Soldatova Y.V., Smolina, A.V., Fedorov B.S., Eremeev A. B., Kotelnikova, R.A. Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine. // Bulletin of experimental biology and medicine. – 2019. – V. 167. – №. 6. – Р. 744-746. https://doi.org/10.1007/s10517-019-04613-x 

• Fayngold I.I., Lozhkin A.D., Smolina A.V., Soldatova Yu.V., Romanova V.S., Obraztsova N.A., Kurmaz S.V., Shtolko V.N., Kotelnikova R.A. Membranotropic properties of fullerene-containing amphiphilic (co)polymers of N-vinylpyrrolidone // Russian Chemical Bulletin. – 2018. – V. 67. – №. 5. – Р. 800-805. https://doi.org/10.1007/s11172-018-2140-5 

• Soldatova Yu.V., Areshidze D.A., Faingold I.I., Poletaeva D.A., Zhilenkov A.V., Troshin P.A., Kotelnikova R.A. Antidiabetic action of water-soluble pentamino acid derivatives of fullerene C60. // Journal of bioenergetics and biomembranes. – 233 Spring st, New York, NY 10013 USA: Springer/Plenum publishers, 2018. – V. 50. – №. 6. – Р. 586.  https://doi.org/10.1007/s10863-018-9775-7 

• Kotelnikova R. A., Smolina A. V., Zhilenkov A. V., Soldatova Yu. V., Faingold I. I., Troshin P. A., Kotelnikov A. I. Interaction of water soluble pentaamino acid fullerene derivatives with membranes of phosphatidylcholine liposomes // Russian Chemical Bulletin. – 2018. – V. 67. – № 2. –  Р. 366—370. https://doi.org/10.1007/s11172-018-2082-y