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Darya A. Poletaeva
InterestsMy research goal is to understand the molecular mechanisms of potential drug molecules activity. More specifically, I am focusing on the interaction of bioactive molecules with the membrane of PC liposomes using a fluorescent probes technique and lipid peroxidation. Also, our laboratory provide studies on streptozotocin-high fat diet diabetic mouse model.
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Soldatova, Y.V.; Faingold, I.I.; Poletaeva, D.A.; Kozlov, A.V.; Emel’yanova, N.S.; Khodos, I.I.; Chernyaev, D.A.; Kurmaz, S.V. Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone. Pharmaceutics 2023, 15, 1388.
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D.A. Poletaeva, I.I. Faingold, Yu.V. Soldatova, A.V. Smolina, M.A. Savushkin, N.A. Sanina, S.M. Aldoshin. Interaction between iron nitrosyl complexes and phosphatidylcholine membranes: a fluorescence study. Russian Journal of Physical Chemistry A, 2023, Vol. 97, No. 5, pp. 822–827.
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Poletaeva, D.A., Kotelnikova, R.A., Faingold, I.I. et al. Electrostatic effects on water-soluble fullerene derivatives interaction with cytochrome c and cytochrome c oxidase. J Biol Phys 49, 269–282 (2023).
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Poletaeva DA, Soldatova YV, Smolina AV, Savushkin MA, Klimanova EN, Sanina NA, Faingold II. The Influence of Cationic Nitrosyl Iron Complex with Penicillamine Ligands on Model Membranes, Membrane-Bound Enzymes and Lipid Peroxidation. Membranes (Basel). 2022 Nov 2;12(11):1088.
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S.V. Kurmaz, N.V. Fadeeva, J.A. Skripets, R.I. Komendant, V.M. Ignatiev, N.S. Emel'yanova, Y.V. Soldatova, I.I. Faingold, D.A. Poletaeva, R.A. Kotelnikova. New water-soluble forms of α-tocopherol: preparation and study of antioxidant activity in vitro. Mendeleev Communications,Volume 32, Issue 1, 2022, Pages 117-119.
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Faingold II, Poletaeva DA, Soldatova YV, Smolina AV, Pokidova OV, Kulikov AV, Sanina NA, Kotelnikova RA. Effects of albumin-bound nitrosyl iron complex with thiosulfate ligands on lipid peroxidation and activities of mitochondrial enzymes in vitro. Nitric Oxide. 2021 Dec 1;117:46-52.
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Kurmaz, S.V., Fadeeva, N.V., Soldatova, Y.V. et al. New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus. J Polym Res 28, 345 (2021).
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Soldatova, Y.V., Areshidze, D.A., Zhilenkov, A.V. et al. Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats. J Nanopart Res 23, 202 (2021).
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Makhaeva GF, Kovaleva NV, Rudakova EV, Boltneva NP, Lushchekina SV, Faingold II, Poletaeva DA, Soldatova YV, Kotelnikova RA, Serkov IV, Ustinov AK, Proshin AN, Radchenko EV, Palyulin VA, Richardson RJ. New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment. Molecules. 2020 Dec 12;25(24):5891.
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Poletaeva, D.A., Faingold, I.I., Soldatova, Y.V. et al. Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine. Bull Exp Biol Med 167, 744–746 (2019).
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Faingold, I.I., Kotelnikova, R.A., Smolina, A.V. et al. Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro. Dokl Biochem Biophys 488, 342–345 (2019).
Scientific Departments
- Institute of Physiologically Active Compounds
- Department of Combustion and Explosion
- Department of Kinetics and Catalysis
- Laboratory of Synthesis of Organic Polyfunctional Materials
- Laboratory of EPR-Spectroscopy of Macromolecules
- Laboratory of Electrochemical Dynamics and Electrolytic Systems
- Laboratory of Molecular Spectroscopy
- Laboratory of Radical Liquid-Phase Reactions
- Laboratory of Complex Catalysts
- Laboratory of Functional Materials for Electronics and Medicine
- Group of Kinetics of Cluster Processes
- Department of Polymers and Composite Materials
- Chemical Engineering Department
- Laboratory of Catalytic Synthesis of Organic Compounds
- Laboratory of Petrochemical Processes
- Laboratory of Physico-Chemical engineering of composite materials
- Laboratory of Gas Chemistry Processes
- Group of Heterogeneous Catalysis Engineering
- Group of Business and Techno-economic Research
- Multiple-access Center “New Petrochemical Processes, Polymer Composites and Adhesives”
- Department of Extreme States of Matter
- Laboratory of Computational Fluid Dynamics
- High Dynamic Pressures Laboratory
- Laboratory of Thermal Properties of Dense Plasma
- Laboratory of Experimental Thermal Physics
- Laboratory of Detonation
- Laboratory of Matter State Equations
- Laboratory of Rheological Properties of Condensed Media upon Impulse Impacts
- Laboratory of Electromagnetic Processes in Shock-Compressed Media
- Group of Chemistry of Impulse Impacts
- Group of Chemical Physics of low temperatures
- Department of Structure of Matter
- Laboratory of Structural Chemistry
- Laboratory of Cryochemistry and Radiation Chemistry
- Laboratory of Kinetic ESR and Molecular Spectroscopy
- Laboratory of Molecular Conductors and Magnets
- Joint Laboratory of Photodynamics of Nanobiostructures
- Group of the Mössbauer spectroscopy and magnetochemistry
- Group of magnetic and spin logical processes and devices
- Radiation Exposure Group "Gammatok-100"
- Department of Nanophotonics
- Department of Functional Materials for Chemical Energy Sources
- Laboratory of Superionics
- Complex of Laboratories for Hydrogen Materials Science
- Laboratory of Materials Engineering for Solid State Devices
- Laboratory of Laser Electrochemistry
- Laboratory of Solid-State Electrochemical Systems
- Laboratory of Electrode Processes in Liquid Systems
- Group of Special Materials
- Department of Kinetics of Chemical and Biological Processes
- Laboratory of Chemical Physics of Ferments
- Laboratory of Molecular Biology
- Laboratory of Kinetic Modeling
- Laboratory of Biologically Active Compounds
- Laboratory of Physico-Chemical Biology of Physiologically Active Compounds
- Group of Stable Radicals
- Group of Free Radical Processes in Biosystems
- Group of Molecular Modeling of Biochemical Processes
- Screening and Preclinical Studies Unit
- Theoretical Department
- Research Center of Nanostructured Materials for Energy Conversion and Storage
- Competence Center of National Technology Initiative