Our research goal is to understand the molecular mechanisms of potential drug molecules activity and the role different proteins play during disease progression. More specifically we are focusing on the interaction of bioactive molecules with the membrane of PC liposomes using a fluorescent probes technique; lipid peroxidation; aldose reductase and monoamine oxidase activity; non-enzymatic glycation of proteins. Also, our laboratory provide studies on streptozotocin-high fat diet diabetic mouse model.

The results from our studies will constitute the foundation for drug discovery and will provide insight into molecular basis of their physicochemical properties.

Kotelnikov Alexandr Ivanovich, Romanova Valentina Semenovna, Bogdanov Gennady Nikolaevich, Konovalova Nina Petrovna, Pisarenko Oleg Ivanovich, Kotelnikova Raisa Alekseevna, Faingold Irina Igorevna, Frog Elena Sergeevna, Bubnov Yury Nikolaevich, Aldoshin Sergei Mikhailovich, Davydov Mikhail Ivanovich“Polyfunctional Fullerene C60 Aminoacid Derivatives”, WO 2009/002203 A1.

• Soldatova, Y.V.; Faingold, I.I.; Poletaeva, D.A.; Kozlov, A.V.; Emel’yanova, N.S.; Khodos, I.I.; Chernyaev, D.A.; Kurmaz, S.V. Design and Investigation of New Water-Soluble Forms of α-Tocopherol with Antioxidant and Antiglycation Activity Using Amphiphilic Copolymers of N-Vinylpyrrolidone. Pharmaceutics 2023, 15, 1388. https://doi.org/10.3390/pharmaceutics15051388

• Poletaeva D.A., Faingold I.I., Soldatova Yu.V., Smolina A.V., Savushkin M.A., Sanina N.A., Aldoshin S.M. Interaction of iron nitrosyl complexes with the membrane of phosphatidylcholine liposomes: a fluorescent study // Journal of Physical Chemistry, Nauka, M., V. 97, No. 5, 2023 P. 617-623. https://doi.org/10.31857/S0044453723050217    

• Soldatova Yu.V., Areshidze D.A., Kozlova M.A., Zhilenkov A.V., Kraevaya O.A., Faingold I.I., Troshin P.A., Kotelnikova R.A. Hypoglycemic and hypolipidemic effect of pentaamino acid fullerene C₆₀ derivative in rats with metabolic disorder. // Journal of Bioenergetics and Biomembranes 2023, https://doi.org/10.1007/s10863-023-09961-y

• Soldatova Yu.V., Zhilenkov A.V., Kraevaya O.A., Troshin P.A., Faingold I.I., Kotelnikova R.A.Antioxidant and antiglycation activity of pentaamino acid derivatives of С₆₀ fullerene. Nanotechnologies in Russia (Nanobiotechnology Reports) 2022,  Vol. 17, № 6, P. 840–845. https://doi.org/10.1134/S2635167622060118

• Poletaeva, D.A.; Soldatova,Y.V.; Smolina, A.V.; Savushkin, M.A.; Klimanova, E.N.; Sanina, N.A.;Faingold, I.I. The Influence of Cationic Nitrosyl Iron Complex with Penicillamine Ligands on Model Membranes, Membrane-Bound Enzymes and Lipid Peroxidation. Membranes 2022, 12 (11), 1088. https://doi.org/10.3390/membranes12111088

• Kurmaz S.V., Fadeeva N.V., Skripets J.A., Komendant R.I., Ignatiev V.M., Emel’yanova N.S., Soldatova Yu.V., Faingold I.I., Poletaeva D.A. and Kotelnikova R.A. New water-soluble forms of a-tocopherol: preparation and study of antioxidant activity in vitro // Mendeleev Communications – 2022. – Vol.32. – P.117–119. https://doi.org/10.1016/j.mencom.2022.01.038

• Faingold I.I., Poletaeva D.A., Soldatova Yu.V., Smolina A.V., Pokidova O.V., Kulikov A.V., Sanina N.A., Kotelnikova R.A. Effects of albumin-bound nitrosyl iron complex with thiosulfate ligands on lipid peroxidation and Activities of mitochondrial enzymes in vitro. //Nitric Oxide, 2021. – Vol.117. –P.46-52  https://doi.org/10.1016/j.niox.2021.10.002  

• Soldatova Yu. V., D.A. Areshidze, A.V. Zhilenkov , O.A. Kraevaya, A.S. Peregudov, D.A. Poletaeva, I. I. Faingold, P. A. Troshin, R. A. Kotelnikova. Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats.// Journal of Nanoparticle Research, 2021. – Vol. 23. – №. 202 P. 1-13 https://doi.org/10.1007/s11051-021-05313-2

• Kurmaz S.V.; N. V. Fadeeva; Soldatova Y. V.; I. I. Faingold; D. A. Poletaeva; V. M. Ignat'ev; N. S. Emel'yanova; G. V. Shilov; R. A. Kotelnikova. New complexes of metformin based on the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate and their activity in experimental type 2 diabetes mellitus. // Journal of Polymer Research, 2021. – Vol. 28. – №. 345. - P. 1-15  https://doi.org/10.1007/s10965-021-02684-x

• Kurmaz S.V., Fadeeva N.V., Grishchuk A.A., Emel’yanova N.S., Ignat’ev V.M., Shilov G.V., Soldatova Yu.V., Faingold I.I., and Kotel’nikova R.A.. Hybrid Materials Based on Dimethylbiguanide (Metformin) and Copolymer of N-Vinylpyrrolidone with Triethylene Glycol Dimethacrylate // Polymer science series A. – 2021. –Vol. 63, No. 2. – P.106-116. –https://doi.org/10.1134/S0965545X2102005X   

• Makhaeva G. F., Kovaleva N.V., Rudakova E.V., Boltneva N. P., Lushchekina S.V., Faingold I.I., Poletaeva D.A., Soldatova Y.V., Kotelnikova R.A., Serkov I.V., Ustinov A. K., Proshin A.N., Radchenko E.V., Palyulin V.A., and Richardson R. J. New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment. Molecules. 2020.  – Vol. 25. – №. 24. – P. 5891. https://doi.org/10.3390/molecules25245891 

• Soldatova Yu. V., Kotelnikova R. A,. Zhilenkov A. V, Faingold I. I., Troshin P. A., Kozlova M. A., Areshidze D. A., and Academician of the RAS Aldoshin S. M. Potassium salt of fullerenylpenta-N-dihydroxytyrosine effects on type 2 diabetes mellitus therapeutic targets. // Doklady Biochemistry and Biophysics, 2019. – Vol. 488. –  № 1. –  P. 320-323.  DOI: https://doi.org/10.1134/S1607672919050089 

• Faingold I.I., Kotelnikova R.A., Smolina A.V., Poletaeva D.A., Soldatova Yu.V., Pokidova O.V., Sadkov A.P., Sanina N.A., Aldoshin S.M. Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro // Doklady Biochemistry and Biophysics. – Pleiades Publishing, 2019. – Vol. 488. – №. 1. – P. 342-345. https://doi.org/10.1134/S1607672919050120

• Poletaeva D.A., Faingold I.I., Soldatova Y.V., Smolina, A.V., Fedorov B.S., Eremeev A. B., Kotelnikova, R.A. Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine. // Bulletin of experimental biology and medicine. – 2019. – V. 167. – №. 6. – Р. 744-746. https://doi.org/10.1007/s10517-019-04613-x

• Fayngold I.I., Lozhkin A.D., Smolina A.V., Soldatova Yu.V., Romanova V.S., Obraztsova N.A., Kurmaz S.V., Shtolko V.N., Kotelnikova R.A. Membranotropic properties of fullerene-containing amphiphilic (co)polymers of N-vinylpyrrolidone // Russian Chemical Bulletin. – 2018. – V. 67. – №. 5. – Р. 800-805. https://doi.org/10.1007/s11172-018-2140-5

• Soldatova Yu.V., Areshidze D.A., Faingold I.I., Poletaeva D.A., Zhilenkov A.V., Troshin P.A., Kotelnikova R.A. Antidiabetic action of water-soluble pentamino acid derivatives of fullerene C60. // Journal of bioenergetics and biomembranes. – 233 Spring st, New York, NY 10013 USA: Springer/Plenum publishers, 2018. – V. 50. – №. 6. – Р. 586.  https://doi.org/10.1007/s10863-018-9775-7

• Kotelnikova R. A., Smolina A. V., Zhilenkov A. V., Soldatova Yu. V., Faingold I. I., Troshin P. A., Kotelnikov A. I. Interaction of water soluble pentaamino acid fullerene derivatives with membranes of phosphatidylcholine liposomes // Russian Chemical Bulletin. – 2018. – V. 67. – № 2. –  Р. 366—370. https://doi.org/10.1007/s11172-018-2082-y