Biological activity of chemical compounds.

Molecular mechanisms of cellular response to cytotoxic effects.

The role of the p53 protein in the regulation of the antioxidant system.

Nanosized systems for targeted delivery of anticancer compounds.

Chemosensitizing properties of hydroxamic acids.

Tretyakov B.A., Gadomsky S.Y., Terentiev A.A. A Reaction of N-Substituted Succinimides with Hydroxylamine as a Novel Approach to the Synthesis of Hydroxamic Acids // Organics. – 2023 – Vol. 4, No. 2 – P. 186-195.

Kurmaz S.V., Ivanova I.I., Emelyanova N.S., Konev D.V., Kurmaz V.A., Filatova N.V., Balakina A.A., Terentiev A.A. Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylate // Mendeleev Commun. – 2023 – Vol. 33, No. 2 – P. 255–258.

Sanina NA, Starostina AA, Utenyshev AN, Dorovatovskii PV, Emel'yanova NS, Krapivin VB, Luzhkov VB, Mumyatova VA, Balakina AA, Terentiev AA, Aldoshin SM. Novel Type of Tetranitrosyl Iron Salt: Synthesis, Structure and Antibacterial Activity of Complex [FeL'2(NO)2][FeL'L"(NO)2] with L'-thiobenzamide and L"-thiosulfate. Molecules. 2022 Oct 14;27(20):6886. doi: 10.3390/molecules27206886.

Kurmaz S.V., Ignatiev V.M., Emel’yanova N.S., Kurmaz V.A., Konev D.V., Balakina A.A., Terentyev A.A. New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity // Pharmaceutics, 2022, 14, 2572, DOI: 10.3390/pharmaceutics14122572

Sanina Nataliya A; Kozub Galina I; Kondrat'eva Tat'yana A; Korchagin Denis V;  Shilov Gennadii V; Morgunov Roman B;  Ovanesyan Nikolai S; Kulikov Alexander V; Stupina Tat'yana S; Terent'ev Alexey A;  Aldoshin Sergey M. Anionic dinitrosyl iron complexes – new nitric oxide donors with selective toxicity to human glioblastoma cells // Journal of Molecular Structure, 2022, 1266, 133506, DOI: 10.1016/j.molstruc.2022.133506

S. V. Kurmaz, I. I. Ivanova, N. V. Fadeevaa E. O. Perepelitsinaa M. A. Lapshina, A. A. Balakina and A. A. Terent’ev New Amphiphilic Copolymers of N-Vinylpyrrolidone with Branched Methacrylic Acid for Biomedical Applications // Polymer Science, Series A, 2022, 64, 434-446, DOI: 10.1134/S0965545X22700237

N.A. Sanina, I.V. Sulimenkov, N.S. Emel’yanova, A.S. Konyukhova, T.S. Stupina, A.A. Balakina, A.A. Terent’ev, S.M. Aldoshin Cationic dinitrosyl iron complexes with thiourea exhibit selective toxicity to brain tumor cells in vitro // Dalton Transactions, 2022, 51, 8893–8905, DOI: 10.1039/D2DT01011A

Sanina N.A., Yakuschenko I.K., Gadomsky S.Ya., Utenyshev A.N., Dorovatovskii P.V., Lazarenko V.A., Emel'yanova N.S., Zagainova E.A., Ovanesyan N.S., Mumyatova V.A., Balakina A.A., Terent'ev A.A., Aldoshin S.M. Synthesis, structure and antibacterial activity of dinitrosyl iron complexes (DNICs) dimers functionalized with 5-(nitrophenyl) -4-H-1,2,4-triazole-3-thiolyls // Polyhedron. – 2022. – 115822. – DOI: 10.1016/j.poly.2022.115822

Yakushchenko I.K., Pozdeeva N.N., Terentiev A.A., Gadomsky S.Y. Effect of the linker nature on the antibacterial activity of structural analogs of octenidine // Russ Chem Bull. – 2022. – Vol. 71. – P. 595–597. – DOI:10.1007/s11172-022-3456-8

Rzhepakovsky I.V., Areshidze D.A., Avanesyan S.S., Grimm W.D., Filatova N.V., Kalinin A.V., Kochergin S.G., Kozlova M.A., Kurchenko V.P., Sizonenko M.N., Terentiev A.A., Timchenko L.D., Trigub M.M., Nagdalian A.A., Piskov S.I. Phytochemical Characterization, Antioxidant Activity, and Cytotoxicity of Methanolic Leaf Extract of Chlorophytum Comosum (Green Type) (Thunb.) Jacq // Molecules. – 2022. – Vol. 27, No. 3. – P.762. DOI: 10.3390/molecules27030762.

Kurmaz S.V., Konev D.V., Kurmaz V.A., Kozub G.I., Ignat'ev V.M., Emel'yanova N.S., Balakina A.A., Terentyev A.A. New nanosized systems with antitumor activity based on the Pt(IV) complexes with nicotinamide ligands and amphiphilic copolymers of N-vinylpyrrolidone and (di)methacrylate // INEOS OPEN. – 2021. – Vol. 4, No. 5. – P. 195-201. – DOI: 10.32931/io2123a

Sanina N.A., Kozub G.I., Kondrat'eva T.A., Stupina T.S., Balakina A.A., Terent'ev A.A., Sulimenkov I.V., Ovanesyan N.S., Dorovatovskii P.V., Khrustalev V.N., Aldoshin S.M. Structure, nitric oxide (NO) generation and antitumor activity of binuclear tetranitrosyl iron complex with 4-aminothiophenolyl as nitrosyl ferredoxins mimic. // Journal of coordination chemistry. – 2021. – Vol. 74. – No. 4-6. – P. 743-761. Doi 10.1080/00958972.2020.1869222

Tatiana S. Kokovina T.S., Gadomsky S.Y., Terentiev A.A., Sanina N.A. A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives // Molecules, 2021, 26(17), 5159; https://doi.org/10.3390/molecules26175159

Belik AY, Rybkin AY, Goryachev NS, Sadkov AP, Filatova NV, Buyanovskaya AG, Talanova VN, Klemenkova ZS, Romanova VS, Koifman MO, Terentiev AA, Kotelnikov AI. Nanoparticles of water-soluble dyads based on amino acid fullerene C60 derivatives and pyropheophorbide: Synthesis, photophysical properties, and photodynamic activity. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Nov 5;260:119885. doi: 10.1016/j.saa.2021.119885.

Makhaeva GF, Lushchekina SV, Boltneva NP, Serebryakova OG, Kovaleva NV, Rudakova EV, Elkina NA, Shchegolkov EV, Burgart YV, Stupina TS, Terentiev AA, Radchenko EV, Palyulin VA, Saloutin VI, Bachurin SO, Richardson RJ. Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold. Eur J Med Chem. 2021 Jun 5;218:113385. doi: 10.1016/j.ejmech.2021.113385.

Yakuschenko I. K., Nataliya N. Pozdeeva, Viktoriya A. Mumyatova, Alexey A. Terentiev and Svyatoslav Ya. Gadomsky. Iso-octenidine: Promising Octenidine Analogue with Improved Solubility. //Current Organic Synthesis, June 2021, v.18, Issue 5, p.1-3. DOI: 10.2174/1570179417666201231104453

Sen' V.D., Balakina A.A., Stupina T.S., Mumyatova V.A., Kulikov A.V., Tikhonov I.V., Terent'ev A.A., Pliss E.M. Amphiphilic chitosan–polyaminoxyls loaded with daunorubicin: Synthesis, antioxidant activity, and drug delivery capacity // International Journal of Biological Macromolecules 193 (2021) 965–979. DOI: 10.1016/j.ijbiomac.2021.10.170.

Lebedeva M.V., Nikonova E.Y., Terentiev A.A., Taranov V.V., Babakov A.V., Nikonov O.S. VPg of Potato Virus Y and Potato Cap-Binding eIF4E Factors: Selective Interaction and Its Supposed Mechanism // Biochemistry (Mosc). – 2021. – Vol. 86, No. 9. – P. 1128-1138. – DOI: 10.1134/S000629792109008X.

Mumyatova V.A., Balakina A.A., Lapshina M.A., Sen' V.D., Kornev A.B., Terent'ev A.A. Influence of Tumor Suppressor p53 Functioning on the Expression of Antioxidant System Genes under the Action of Cytotoxic Compounds // Bull Exp Biol Med. – 2020. – Vol. 169, No. 1. – P. 169-175. – DOI: 10.1007/s10517-020-04844-3.

Makhaeva G.F., Kovaleva N.V., Boltneva N.P., Lushchekina S.V., Rudakova E.V., Stupina T.S., Terentiev A.A., Serkov I.V., Proshin A.N., Radchenko E.V., Palyulin V.A., Bachurin S.O., Richardson R.J. Conjugates of Tacrine and 1,2,4-thiadiazole Derivatives as New Potential Multifunctional Agents for Alzheimer's Disease Treatment: Synthesis, Quantum-Chemical Characterization, Molecular Docking, and Biological Evaluation // Bioorganic chemistry. – 2020. – Vol. 94. – P. 103387. DOI: 10.1016/j.bioorg.2019.103387 [Q1]

Rybkin A.Yu., Belik A.Yu., Goryachev N.S., Mikhaylov P.A., Kraevaya O.A., Filatova N.V., Parkhomenko I.I., Peregudov A.S., Terent'ev A.A., Larkina E.A., Mironov A.F., Troshin P.A., Kotelnikov A.I. Self-assembling nanostructures of water-soluble fullerene[60]–chlorin e6 dyads: Synthesis, photophysical properties, and photodynamic activity // Dyes and Pigments. – 2020. – Vol. 180. – P. 108411. DOI: 10.1016/j.dyepig.2020.108411 [Q1]

Balakina A.A., Raevskaya T.A., Pavlov V.S., Mumyatova V.A., Goncharova S.A., Terent'ev A.A. Nrf2-Dependent Expression of Glutathione Antioxidant System Genes and Redox Status in Cells of In Vivo Drug-Resistant Murine P388 Leukemia Strains // Bull Exp Biol Med. – 2020. – Vol. 169, No. 2. – P. 249-253. – DOI 10.1007/s10517-020-04861-2.

Kurmaz S.V., Fadeeva N.V., Fedorov B.S., Kozub G.I., Emel’yanova N.S., Kurmaz V.A., Manzhos R.A., Balakina A.A., Terentyev A.A. New antitumor hybrid materials based on PtIV organic complex and polymer nanoparticles consisting of N-vinylpyrrolidone and (di)methacrylates // Mendeleev Communications. – 2020. – Vol. 30. – No. 1. – P. 22-24. DOI: 10.1016/j.mencom.2020.01.007 [Q3]

Lapshina M., Ustyugov A., Baulin V., Terentiev A., Tsivadze A., Goldshleger N. Crown- And Phosphoryl-Containing Metal Phthalocyanines in Solutions of poly(N-vinylpyrrolidone): Supramolecular Organization, Accumulation in Cells, Photo-Induced Generation of Reactive Oxygen Species, and Cytotoxicity // Journal of photochemistry and photobiology. B, Biology. – 2020. – Vol. 2020. – P. 111722. DOI: 10.1016/j.jphotobiol.2019.111722 [Q1-Q2]

Trigub М.М., Filatova N.V., Areshidze D.А., Sen' V.D., Terentiev А.А. Comparison of the Effect of Platinum (IV) Complexes on Spheroids and Monolayer Culture of HeLa Cells // Bull Exp Biol Med. – 2020. – Vol. 168, No. 4. – P. 583-588. – DOI: 10.1007/s10517-020-04757-1.

Dmitrieva M.V., Gerasimova E.V., Terent’ev A.A., Dobrovol’skii Yu.A., Zolotukhina E.V. Electrochemical Peculiarities of Mediator-Assisted Bioelectrocatalytic Oxidation of Glucose by a New Type of Bioelectrocatalyst // Russian Journal of Electrochemistry. – 2019. – Vol. 55, No. 9. – P. 889–899. – DOI: 10.1134/S1023193519090064.

Katkova M.A., Zabrodina G.S., Zhigulin G.Yu., Baranov E.V., Trigub M.M., Terentiev A.A., Ketkov S.Yu. The first water-soluble polynuclear metallamacrocyclic Sr(ii)–Cu(ii) complex based on simple glycinehydroximate ligands // Dalton Transactions. – 2019. – Vol. 48. – P. 10479-10487.

Kurmaz S.V., Sen’ V.D., Kulikov A.V., Konev D.V., Kurmaz V.A., Balakina A.A., Terent’ev A.A. Polymer nanoparticles of N-vinylpyrrolidone loaded with an organic aminonitroxyl platinum (iv) complex. Characterization and investigation of their in vitro cytotoxicity // Russian Chemical Bulletin. – 2019. – Vol. 68, No. 9. – P. 1769–1779. – DOI: 10.1007/s11172-019-2623-z.

Mumyatova V.A., Kozub G.I., Kondrat’eva T.A., Terent’ev A.A., Sanina N.A. Antibacterial activity of [1Fe-2S]- and [2Fe-2S]-nitrosyl complexes as nitric oxide donors // Russian Chemical Bulletin. – 2019. – Vol. 68, No. 5. – P. 1025–1030. – DOI: 10.1007/s11172-019-2514-3.

Balakina A.A., Raevskaya T.A., Pavlov V.S., Mumyatova V.A., Goncharova S.A., Terent’ev A.A. Activity of Antioxidant Enzymes and Content of Reduced Glutathione in Cells of Drug-Resistant Murine Leukemia P388 Strains // Bulletin of Experimental Biology and Medicine. – 2019. – Vol. 167, No. 3. – P. 339–342. – DOI: 10.1007/s10517-019-04522-z.

Rodin M., Romanova L., Lapshina M., Terent'ev A., Tarasov A. Synthesis and properties of polyurethane hydrogel based on β-cyclodextrin partial nitrates and poly(ethylene glycol) // Macromolecular Symposia, 2019, V. 385, No. 1, P. 1800161-1800166. doi: 10.1002/masy.201800161

Mumyatova V.A., Balakina A.A., Sen' V.D., Pliss E.M., Terent'ev A.A. Effect of Chitosan-(Poly)Nitroxides on Normal and Tumor Cells under Conditions of Induced Oxidative Stress // Bull Exp Biol Med. – 2019. – Vol. 166. No. 6. – P. 779-784. – DOI: 10.1007/s10517-019-04439-7.

Balakina A.A., Mumyatova V.A., Pliss E.M., Terent’ev A.A., Sen’ V.D. Antioxidant properties of chitosan-(poly)nitroxides under induced oxidative stress // Russian Chemical Bulletin. – 2018. – Vol 67, No. 11. – P. 2135–2140. – DOI: 10.1007/s11172-018-2341-y.

Stupina T, Balakina A, Kondrat'eva T, Kozub G, Sanina N, Terent'ev A. NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells // Scientia Pharmaceutica 2018 Oct 11;86(4). pii: E46. doi: 10.3390/scipharm86040046.

M. A. Lapshina, S. I. Norko, V. E. Baulin, A. A. Terentiev, A. Yu. Tsivadze, N. F. Goldshleger Magnesium Octa[(4’-benzo-15-crown-5)oxy]phthalocyanine in Phosphate Buffer: Supramolecular Organization, Cytotoxicity and Accumulation/Localization in Tumor Cells of HeLa // Macroheterocycles. 2018. 11(4). P. 396-403. doi: 10.6060/mhc180899l