Nitrogen monoxide donors, reactions of nitrosyl iron complexes in model systems, bioinorganic chemistry

Laureate of the Prize of the Governor of the Moscow Region in the fields of science, technology, engineering and innovation for young scientists and specialists in 2022

Project leadership experience

• Russian Science Foundation Grant № 22-73-10049 «Synthesis, theoretical and experimental studies of promising vasodilators based on nitrosyl iron complexes in biological systems» (2022-2025) https://rscf.ru/en/project/22-73-10049/

• Russian Science Foundation Grant № 20-73-00316 «Investigation of the transformation processes of a promising NO donor, a nitrosyl iron complex with N-ethylthiourea ligands, in model biological systems in vitro» (2020-2022)  https://rscf.ru/en/project/20-73-00316/

• Grant of the President No. МК-1634.2021.1.3 "Physicochemical mechanisms of transformation of promising inhibitors of Ca²⁺ - ATPase, nitrosyl iron complexes with thiourea and its derivatives in model biological systems." (2021-2022)

• O.V. Pokidova, V.O. Novikova, N.S. Emel’yanova, A.Yu. Kormukhina, A.V. Kulikov, A.N. Utenyshev, V.A. Lazarenko, N.S. Ovanesyan, A.A. Starostina, N.A. Sanina, (2023). Nitrosyl Iron Complex with 3.4-Dichlorothiophenolyl Ligands: Synthesis, Structure and Its Reactions with targets–carriers of nitrogen oxide (NO) in vivo. Dalton Transactions, 2023. 52, 2641-2662  DOI:10.1039/D2DT04047F https://pubs.rsc.org/en/content/articlelanding/2023/dt/d2dt04047f/unauth

• G.I. Kozub, D.V. Korchagin, A.I. Dmitriev, A.N. Utenyshev, K.V. Bozhenko, G.V. Shilov, N.S. Ovanesyan, O.V. Pokidova, T.А. Kondrat'eva, M.V. Zhidkov, N.N. Efimov, T.N. Rudneva, S.М. Aldoshin. Mononuclear mononitrosyl iron complex with 8-mercaptoquinoline. Synthesis, structure and properties// Journal of Molecular Structure 2023, 135285 https://doi.org/10.1016/j.molstruc.2023.135285 https://www.sciencedirect.com/science/article/abs/pii/S0022286023003824

•  V.O. Novikova, N.S. Emel’yanova, A.V. Kulikov, A. V. Maryina, O. V. Pokidova, N. A. Sanina. Nitrosyl iron complex with N-ethylthiourea ligands: reactions with hemoglobin.//Russ Chem Bull 72, 902–911 (2023). https://doi.org/10.1007/s11172-023-3853-8

https://link.springer.com/article/10.1007/s11172-023-3853-8

• O.V. Pokidova, N.S. Emel'yanova, A.Yu. Kormukhina, V.O. Novikova, A.V. Kulikov, A.I. Kotelnikov, N.A. Sanina, Albumin as prospective carrier of nitrosyl iron complex with thiourea and thiosulfate ligands under aerobic conditions. Dalton Transactions, 2022, 51, 6473 – 6485. https://doi.org/10.1039/D2DT00291D

https://pubs.rsc.org/en/content/articlelanding/2022/dt/d2dt00291d/unauth

• Pokidova, О. V., Emel'yanova N. S., Psikha B. L., Kulikov A. V., Konyukhova A. S., Kotelnikov A. I., Sanina, N. A. (2022) Effect of solvents and glutathione on the decomposition of the nitrosyl iron complex with N-ethylthiourea ligands: An experimental and theoretical study. Journal of Inorganic Biochemistry, 235, 111926. https://doi.org/10.1016/j.jinorgbio.2022.111926

https://www.sciencedirect.com/science/article/abs/pii/S016201342200215X

• Pokidova, O. V., Psikha, B. L., Emel’yanova, N. S., Gutsev, L. G., Novikova, V. O., Zagainova, E. A., Sanina, N. A. (2022). Features of the decomposition of the nitrosyl iron complex with thiourea ligands under aerobic conditions: experiment and kinetic and quantum chemical modeling. Russian Chemical Bulletin, 71(8), 1604-1613.https://doi.org/10.1007/s11172-022-3569-0

https://link.springer.com/article/10.1007/s11172-022-3569-0

• Pokidova O.V., Kormukhina A.Y., Kotelnikov A.I., Rudneva T.N., Lyssenko K.A., Sanina N.A. Features of the decomposition of cationic nitrosyl iron complexes with N-ethylthiourea and penicillamine ligands in the presence of albumin. Inorganica Chimica Acta, 2021, 524, 120453. DOI: 10.1016/j.ica.2021.120453

https://www.sciencedirect.com/science/article/pii/S0020169321002097?casa_token=XYQCAxaUU9UAAAAA:I5pRcC9tiLAT1IF3a9krpYo8SEjO6f0dB2hxEUFUiWgfKw7vtGcGQC63S9ZLfaGLDJwnarKDqBU

• Faingold I.I., Poletaeva D.A., Soldatova Y.V., Smolina A.V., Pokidova O.V., Kulikov A.V., Sanina N.A., Kotelnikova, R. A. Effects of albumin-bound nitrosyl iron complex with thiosulfate ligands on lipid peroxidation and activities of mitochondrial enzymes in vitro. Nitric Oxide, 2021, 117, 46-52. DOI: 10.1016/j.niox.2021.10.002

https://www.sciencedirect.com/science/article/pii/S1089860321001063?casa_token=5wZcOq_LF6UAAAAA:DpwOUS5KLbw6LEmxBMrrdmZwEO4Xi0_Mzp4ejpt5rgqMoVS1JLmOjhzw7FjyYAHN-9d4eSYVpMw

• Emel'yanova N.S., Gutsev L.G., Pokidova O.V., Shestakov A.F., Sanina N.A.,  Aldoshin S.M. Investigation of the interaction of the cationic nitrosyl iron complex [Fe(SC(NH2)2)2(NO)2]+ with molecular oxygen. Inorganica Chimica Acta, 2021, 522, 120361. DOI: 10.1016/j.ica.2021.120361

https://www.sciencedirect.com/science/article/pii/S0020169321001171?casa_token=YXb32yLV1LMAAAAA:WBhsmjKKQ8TGXtfqAPPtGjjlEgsWLSv3K2DO07ly80wv-l8Qjzs3py9js2Jg8bYn0HHT_nNYC4w

• Sanina N.A., Isaeva Y.A., Utenyshev A.N., Dorovatovskii P.V., Ovanesyan N.S., Emel'yanova N.S., Pokidova O.V, Tat'yanenko L.V., Sulimenkov I.V., Kotel'nikov A.I., Aldoshin S.M. Synthesis, structure, and PDE inhibiting activity of the anionic DNIC with 5-(3-pyridyl)-4H-1, 2, 4-triazole-3-thiolyl, the nitric oxide donor. Inorganica Chimica Acta, 2021, 527, 120559. DOI: 10.1016/j.ica.2021.120559

https://www.sciencedirect.com/science/article/pii/S0020169321003157?casa_token=oy_TtNnAa6EAAAAA:9Xy9dtnvNy7D7zY8J-X-TSTNdFudmz7nlzoDGr7IqseZYxDSoM_bmTbdhuwESWSlCukxUK74evU

• Pokidova О.V., Luzhkov V.B., Emel'yanova N.S., Krapivin V.B., Kotelnikov A.I., Sanina N.A., Aldoshin S.M. Effect of albumin on the transformation of dinitrosyl iron complexes with thiourea ligands. Dalton Transactions, 2020, 49(36), 12674-12685. DOI: 10.1039/D0DT02452J

https://pubs.rsc.org/en/content/articlelanding/2020/dt/d0dt02452j/unauth

• Pokidova O., Rudneva T., Tretyakov B., Kotelnikova R., Kotelnikov A., Aldoshin S. Influence of hemoglobin and albumin on the NO donation effect of tetranitrosyl iron complex with thiosulfate. Nitric Oxide. 2020, V. 94, p. 69-72 DOI: 10.1016/j.niox.2019.10.010

https://www.sciencedirect.com/science/article/pii/S1089860319302691

• Pokidova O.V., Psikha B.L., Kormukhina A.Y., Kotel’nikov A.I., Fedorov B.S.  Mechanism of the 2-ethyl-3-hydroxy-6-methylpyridinium 2-nitroxysuccinate reduction in nitrite-generating systems. Mendeleev Communications, 2020, 30(4), 482-484. DOI 10.1016/j.mencom.2020.07.025

https://www.sciencedirect.com/science/article/abs/pii/S0959943620301966

• Pokidova O. V., Emel'yanova N. S., Psikha B. L., Kulikov A. V., Tretyakov B. A., Kotel'nikov A. I.,  Aldoshin, S. M. Decomposition of the binuclear nitrosyl iron complex with thiosulfato ligands in aqueous solutions: experimental and theoretical study. Inorganica Chimica Acta, 502 (2020) 119369 DOI: 10.1016/j.ica.2019.119369

https://www.sciencedirect.com/science/article/pii/S002016931931518X

• Pokidova, О. V., Emel’yanova, N. S., Psikha, B. L., Sanina, N. A., Kulikov, A. V., Kotel’nikov, A. I., & Aldoshin, S. M.  Transformation of mononuclear dinitrosyl iron complex (DNIC) with thiourea in glutathione aqueous solution. Journal of Molecular Structure. 2019. V.1192, P. 264-273 DOI: 10.1016/j.molstruc.2019.05.005

https://www.sciencedirect.com/science/article/pii/S0022286019305575?via%3Dihub

• Emel’yanova, N. S., Pokidova, O. V., Sanina, N. A., Aldoshin, S. M. TDDFT-modeling of theoretical UV spectra of binuclear sulfur-containing iron nitrosyl clusters and products of their decomposition. Russian Chemical Bulletin, 2019, 68(12), 2190-2196. DOI 10.1007/s11172-019-2687-9

https://link.springer.com/article/10.1007/s11172-019-2687-9