Medical Equipment

The Institute of Problems of Chemical Physics of the RAS

DIAGNOSTIC TEST STRIPS FOR EXPRESS ANALYSIS OF HUMAN BIOLOGIC LIQUIDS

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■ Based on the examination of specific enzymatic and chemical reactions, the diagnostic system for a wide range of human diseases has been developed. It is grounded on the analysis of biologic liquids of organisms by express methods based on the «dry chemistry» concept.

 

WATER SOLUBLE NITROSYL IRON COMPLEXES WITH NATURAL LIGANDS -A NEW FAMILY OF ANTI-TUMOR AGENTS FOR MONOTHERAPY OF CANCER

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▼ Nitrosyl [2Fe-2S] complexes comprising functional sulfur-containing ligands, synthetic models of natural depots of NO in cells, have been proposed as hybrid preparations for monotherapy of solid tumors. Sulfur-containing ligands are known to be reversible inhibitors of synthesis of cell DNA and are widely used in biochemical and medical experiments to suppress the growth of solid tumors of different genesis. As the other component of a hybrid molecule, the NO group is a key signal molecule controlling the tumor growth.

 

NEW PREPARATION FOR COMBINED CHEMOTHERAPY OF ONCOLOGICAL DISEASES
 

alt♦ The nitroxyl complex of Pt(IV), namely, [e-ammin-c/-(4-amino-2,2,6,6-tetramethylpiperidin-l-oxyl)-a,/-bis(acetato)-b.t-dichloroplatinum(IV)] (BC118) has been synthesized and tested as a cytostatic agent.
 

 

GEL-BASED COMPOSITES AS PROPHYLAXIS OF SECONDARY NECROSIS IN THE TREATMENT OF GUNSHOT WOUNDS

alt♦ Based on the up-to-date concept of free-radical nature of secondary traumatic phenomena at wound damages of various genesis (mainly, shotgun), the treatment at early stages has been suggested, which combines the effect of radical reactions inhibitors preventing the necrosis development and of substances accelerating the regeneration of damaged tissues.

 

HIGHLY EFFICIENT ANTISEPTIC COMPOSITIONS BASED ON PYRIDINE DERIVATIVES

alt♦ The process for preparation of a disinfectant based on l,10-di(4-octylaminopyridinium-l)decane dichloride (DOPD) has been developed for production of antiseptic materials.
♦ Disinfectant «Aquanidine» comprising 0.1% of DOPD has been tested to show high bactericidal, fungicidal and viricidal activity, particularly, towards viruses of poliomyelitis, herpes simplex, HIV, hepatitis Сand bird flu virus A.
♦ The developed compositions can be used for quick hands disinfection for medical, school and kindergarten personnel as well as for disinfection of medical instruments and equipment, and for residential use. The compositions show durable (up to 6 hours) antiviral effect.